How is flumazenil administered when treating a diazepam overdose
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Lancet 2: 510, 1985 PubMed CAS Article Google Scholar Zuurmond WWA, van Leeuwen L, Helmers JHJH. Recovery from fixed-dose midazolam-induced anaesthesia and antagonism with flumazenil for outpatient arthroscopy. Acta Anaesthesiologica Scandinavica 33: 160–163, 1989 PubMed CAS Article Google Scholar How do you administer flumazenil?The recommended starting dose is 200 micrograms administered intravenously over 15 seconds. If the required level of consciousness is not obtained within 60 seconds, a further dose of 100 micrograms can be injected and repeated at 60-second intervals, up to a maximum dose of 1000 micrograms.
Why flumazenil is repeatedly administered in diazepam overdose?It improves the level of consciousness in patients with benzodiazepine overdose; however, resedation may occur within one to two hours after administration, so repeated doses or a continuous infusion may be required to maintain therapeutic efficacy.
Is flumazenil an antidote for diazepam?Flumazenil (Romazicon®) is the antidote for benzodiazepines, such as diazepam (Valium®), lorazepam (Ativan®), and midazolam (Versed®), and must be administered intravenously.
What is flumazenil and how does it work?Flumazenil is a benzodiazepine antagonist. It competitively inhibits the activity of benzodiazepine and non-benzodiazepine substances that interact with benzodiazepine receptors site on the GABA/benzodiazepine receptor complex. It can also reverse the binding of benzodiazepines to benzodiazepine receptors.
How fast do you push flumazenil?Adult Patients
For the reversal of the sedative effects of benzodiazepines administered for conscious sedation, the recommended initial dose of flumazenil injection is 0.2 mg (2 mL) administered intravenously over 15 seconds.
Does flumazenil treat benzodiazepine overdose?Flumazenil is a benzodiazepine receptor antagonist FDA approved in 1992 for reversal of benzodiazepine overdose and postoperative sedation from benzodiazepine anesthetics. Flumazenil is a 1,4-benzodiazepine derivative that has a high affinity for the benzodiazepine binding site on the GABA receptor.
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